The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Radiation-induced lung injury (RILI)
Radioactive 90Y beads can gain access to the pulmonary circulation via shunting of compound through the liver tumor following prehepatic infusion. The damage from infusional radiation offers distinctive imaging. The opacities are generally disseminated. They tend to stay at some distance of the pleulal surface. Possibly because beads containing beta-emitting 90Y lodge within 40-50 µm diameter arterioles.
Publications
Radiation injury to the lung caused by yttrium-90 resin microspheres (SIR-Spheres) diagnosed by transbronchial lung biopsy.
American journal of clinical pathology. 2026;165(5)
Radiation Pneumonitis after Yttrium-90 Radioembolization: A Systematic Review.
Journal of vascular and interventional radiology : JVIR. 2025;36(2):207-218
Radiation pneumonitis following Yttrium-90 radioembolization: A Korean multicenter study.
Frontiers in oncology. 2023;13:977160
Radiation pneumonitis following yttrium-90 radioembolization: case report and literature review.
Journal of vascular and interventional radiology : JVIR. 2012;23(5):669-74