The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Anaphylaxis-Anaphylactoid reaction (can be fatal)
Publications
Anaphylaxis spares no drug: A report of diclofenac-induced anaphylaxis mimicking post-laparoscopy respiratory complication.
Saudi journal of anaesthesia. 2023;17(2):236-238
Anaphylaxis to diclofenac: nine cases reported to the Allergy Vigilance Network in France.
Allergy. 2014;69(10):1420-3
Oral drug challenges in non-steroidal anti-inflammatory drug-induced urticaria, angioedema and anaphylaxis.
Internal medicine journal. 2012;42(6):665-71
Anaphylactic reaction to intravenous diclofenac.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2011;15(1):37-9
Acute ST-segment elevation myocardial infarction associated with diclofenac-induced anaphylaxis: case report.
American journal of critical care : an official publication, American Association of Critical-Care Nurses. 2009;18(4):388, 386-7
Leone R, Conforti A, Venegoni M, Motola D, Moretti U, Meneghelli I, Cocci A, Sangiorgi Cellini G, Scotto S, Montanaro N, Velo G
Drug-induced anaphylaxis : case/non-case study based on an italian pharmacovigilance database.
Drug safety. 2005;28(6):547-56
A population based case-cohort study of drug-induced anaphylaxis.
British journal of clinical pharmacology. 1993;35(4):400-8