The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIX.e

Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

Publications

Perez-Alvarez R, Pérez-de-Lis M, Ramos-Casals M,

Biologics-induced autoimmune diseases.

Current opinion in rheumatology 2013 Jan;25;56-64 — 2013 Jan — 56-64

Ishikawa Y, Yukawa N, Kawabata D, Ohmura K, Fujii T, Usui T, Mimori T

A case of antisynthetase syndrome in a rheumatoid arthritis patient with anti-PL-12 antibody following treatment with etanercept.

Clinical rheumatology 2011 Mar;30;429-32 — 2011 Mar — 429-32

Ramos-Casals M, Roberto-Perez-Alvarez , Diaz-Lagares C, Cuadrado MJ, Khamashta MA,

Autoimmune diseases induced by biological agents: a double-edged sword?

Autoimmunity reviews 2010 Jan;9;188-93 — 2010 Jan — 188-93

Ramos-Casals M, Brito-Zerón P, Muñoz S, Soria N, Galiana D, Bertolaccini L, Cuadrado MJ, Khamashta MA

Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases.

Medicine 2007 Jul;86;242-51 — 2007 Jul — 242-51