The Drug-Induced Respiratory Disease Website and App

Cyanoacrylate (N-butyl-2-cyanoacrylate-Histoacryl)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.af

Cyanoacrylate pulmonary embolism

Publications

Chatani K, Ihori H, Ohara K, Nonomura M, Kameyama T, Inoue H

A Fatal Case of Acute Pulmonary Embolism after Cyanoacrylate Closure for Varicose Veins.

Annals of vascular diseases. 2026;19(1)

Pietrasik A, Gąsecka A, Chojecka D, Pytlos J, Rymuza B, Główczyńska R, Banaszkiewicz M, Darocha S, Kurzyna M

Iatrogenic pulmonary embolism with cyanoacrylate - to remove, or to leave?

Kardiologia polska. 2021;79(6):706-707

Frassei JDS, Franco CS, Brambilla VR, Loureiro BMC, Kiebert CDS, Fonseca EKUN, Ando SM, Sawamura MVY

Cyanoacrylate pulmonary embolism after endoscopic sclerotherapy of gastric varices.

Einstein (Sao Paulo, Brazil). 2021;19:eAI5778