The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.d

Pleural/pericardial effusion, ANA positive (DI lupus)

Publications

Shovman O, Tamar S, Amital H, Watad A, Shoenfeld Y

Diverse patterns of anti-TNF-α-induced lupus: case series and review of the literature.

Clinical rheumatology. 2018;37(2):563-568

Kelly D, O'Connell O, Henry M

Adalimumab-induced lupus serositis.

BMJ case reports. 2015;2015

Puertas-Abreu E, Polanco ER, Azocar M, Mundarain LA, Nuñez-Sotelo CM, Montaño R, Vivas FH, Noguera ZT, Marín F, Bellorin O, Rivas JG, Toro E, Benzaquen E, Rauseo M, Gutiérrez González LA, GRUPO GRUVES: grupo Venezolano para el Estudio de las Espondiloartr

Onset of lupus like syndrome in patients with spondyloarthritis treated with anti-TNF-α.

International archives of medicine. 2012;5(1):7

Wetter DA, Davis MD

Lupus-like syndrome attributable to anti-tumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic.

Mayo Clinic proceedings. 2009;84(11):979-84

Ramos-Casals M, Brito-Zerón P, Muñoz S, Soria N, Galiana D, Bertolaccini L, Cuadrado MJ, Khamashta MA

Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases.

Medicine. 2007;86(4):242-251

Mohan AK, Edwards ET, Coté TR, Siegel JN, Braun MM

Drug-induced systemic lupus erythematosus and TNF-alpha blockers.

Lancet (London, England). 2002;360(9333):646