The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary fibrosis
Separation from RA-related pulmonary fibrosis can be extremely difficult (PMID 23791462)
Publications
Tumor necrosis factor inhibitors and lung disease: a paradox of efficacy and risk.
Seminars in arthritis and rheumatism 2010 Oct;40;147-63 — 2010 Oct — 147-63
Interstitial pneumonitis associated with infliximab therapy.
The Journal of rheumatology 2006 Jun;33;1189-93 — 2006 Jun — 1189-93