The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

Publications

Nazer L, Alnajjar T, Salah S, Khzouz J, Alfaqeer N, Qandeel M

Fatal case of cryptogenic organizing pneumonia associated with everolimus.

Annals of Saudi medicine 2014 Sep-Oct;34;437-9 — 2014 Sep-Oct — 437-9

Expósito V, de Prada JA, Gómez-Román JJ, González-Vilchez F, Llano-Cardenal M, García-Camarero T, Fernández-Valls M, Ruano J, Martín-Durán R

Everolimus-related pulmonary toxicity in heart transplant recipients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008 Jul;27;797-800 — 2008 Jul — 797-800

Carreño CA, Gadea M

Case report of a kidney transplant recipient converted to everolimus due to malignancy: resolution of bronchiolitis obliterans organizing pneumonia without everolimus discontinuation.

Transplantation proceedings 2007 Apr;39;594-5 — 2007 Apr — 594-5