The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Murakami Y, Fujita T, Wakatabe Y, Iwamura M

A Fatal Case of Life-Threatening Interstitial Pneumonitis Induced by Everolimus for Metastatic Renal Cell Carcinoma: A Comment about the Increased Risk of Interstitial Lung Disease in Japanese.

Case reports in urology 2019;2019;2703871 — 2019 — 2703871

Arunachalam A, Ali SR, Wakefield BJ, Lane CR, Mehta AC

Everolimus induced pneumonitis in a lung transplant recipient.

Oxford medical case reports 2018 Apr;2018;omy008 — 2018 Apr — omy008

Tejwani V, Panchabhai TS, Kotloff RM, Mehta AC

Complications of Lung Transplantation: A Roentgenographic Perspective.

Chest 2016 06;149;1535-45 — 2016 06 — 1535-45

Depuydt P, Nollet J, Benoit D, Praet M, Caes F

Fatal acute pulmonary injury associated with everolimus.

The Annals of pharmacotherapy 2012 Mar;46;e7 — 2012 Mar — e7

White DA, Camus P, Endo M, Escudier B, Calvo E, Akaza H, Uemura H, Kpamegan E, Kay A, Robson M, Ravaud A, Motzer RJ

Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma.

American journal of respiratory and critical care medicine 2010 Aug 01;182;396-403 — 2010 Aug 01 — 396-403

Otton J, Hayward CS, Keogh AM, Glanville AR, Macdonald PS

Everolimus-associated pneumonitis in 3 heart transplant recipients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009 Jan;28;104-6 — 2009 Jan — 104-6

Alexandru S, Ortiz A, Baldovi S, Milicua JM, Ruíz-Escribano E, Egido J, Plaza JJ

Severe everolimus-associated pneumonitis in a renal transplant recipient.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Oct;23;3353-5 — 2008 Oct — 3353-5