The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.a

Pulmonary embolism - Venous thrombosis/thromboembolism

Publications

Bhardwaj Shah A, Naidu SB

Pulmonary embolus associated with a rare provoking factor: recreational nitrous oxide use.

BMJ case reports 2022 Mar 14;15; — 2022 Mar 14

Sun W, Liao JP, Hu Y, Zhang W, Ma J, Wang GF

Pulmonary embolism and deep vein thrombosis caused by nitrous oxide abuse: A case report.

World journal of clinical cases 2019 Dec 06;7;4057-4062 — 2019 Dec 06 — 4057-4062