The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

A class effect among several gliptins is plausible. Cases pending

Publications

Ohara N, Kaneko M, Sato K, Maruyama R, Furukawa T, Tanaka J, Kaneko K, Kamoi K

Vildagliptin-induced acute lung injury: a case report.

Journal of medical case reports 2016 Aug 12;10;225 — 2016 Aug 12 — 225

Kuse N, Abe S, Kuribayashi H, Inomata M, Saito H, Fukuda Y, Gemma A

A case of vildagliptin-induced interstitial pneumonia.

Respiratory medicine case reports 2016;18;10-3 — 2016 — 10-3