The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.n

Hemopericardium - Bloody pericardial effusion

Publications

Ambat J, Patel S, Pathak PR, Antony M, Basu AK, Sto Domingo FG, Vu PQ

Apixaban-Induced Spontaneous Hemorrhagic Cardiac Tamponade.

Cureus. 2024;16(3):e55476

Aguilar-Gallardo JS, Das S, Reddy P, Mahmood K, Fox A

Clinically Ambiguous Hemorrhagic Cardiac Tamponade Associated with Apixaban.

Cureus. 2022;14(4):e24290

Cinelli M, Uddin A, Duka I, Soomro A, Tamburrino F, Ghavami F, Lafferty J

Spontaneous Hemorrhagic Pericardial and Pleural Effusion in a Patient Receiving Apixaban.

Cardiology research. 2019;10(4):249-252

Asad ZUA, Ijaz SH, Chaudhary AMD, Khan SU, Pakala A

Hemorrhagic Cardiac Tamponade Associated with Apixaban: A Case Report and Systematic Review of Literature.

Cardiovascular revascularization medicine : including molecular interventions. 2019;20(11S):15-20