The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Liles NW, Page EE, Liles AL, Vesely SK, Raskob GE, George JN

Diversity and severity of adverse reactions to quinine: A systematic review.

American journal of hematology. 2016;91(5):461-6

Raine D, Lee A, Wiedmann R

Flash pulmonary oedema: a rare but serious side effect of quinine sulphate.

BMJ case reports. 2012;2012

Everts RJ, Hayhurst MD, Nona BP

Acute pulmonary edema caused by quinine.

Pharmacotherapy. 2004;24(9):1221-4

Krantz MJ, Dart RC, Mehler PS

Transient pulmonary infiltrates possibly induced by quinine sulfate.

Pharmacotherapy. 2002;22(6):775-8

Dyson EH, Proudfoot AT, Prescott LF, Heyworth R

Death and blindness due to overdose of quinine.

British medical journal (Clinical research ed.). 1985;291(6487):31-3