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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Iino M

Interstitial pneumonitis associated with the immunomodulatory drugs thalidomide and lenalidomide.

International journal of hematology. 2012;95(2):223-4

Coates S, Barker A, Spurgeon S

Reversible pulmonary toxicity due to lenalidomide.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2012;18(2):284-6

Kang MH, Ju JH, Kim HG, Kang JH, Jeon KN, Kim HC, Lee GW

Thalidomide induced nonspecific interstitial pneumonia in patient with relapsed multiple myeloma.

The Korean journal of internal medicine. 2010;25(4):447-9

Lerch E, Györik S, Feilchenfeldt J, Mazzucchelli L, Quadri F

A case of lenalidomide-induced hypersensitivity pneumonitis.

Onkologie. 2010;33(5):249-52

Pretz J, Medeiros BC

Thalidomide-induced pneumonitis in a patient with plasma cell leukemia: No recurrence with subsequent lenalidomide therapy.

American journal of hematology. 2009;84(10):698-9

Wyplosz B, Lerolle U, Israël-Biet D, Dougados J, Lillo-Le Louët A, Ghez D, Pouchot J

Thalidomide-induced pneumonitis.

European journal of internal medicine. 2008;19(7):e57-8

Thornburg A, Abonour R, Smith P, Knox K, Twigg HL 3rd

Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide.

Chest. 2007;131(5):1572-4

Díaz García B, de Pablo Gafas A, Ferreiro Alvarez MJ

[Lung toxicity due to thalidomide].

Archivos de bronconeumologia. 2003;39(5):240