The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LII.d

Esophageal toxicity

Publications

Figuero Pérez L, Olivares-Hernández A, Amores-Martín A, Cruz-Hernández JJ, Fonseca-Sánchez E

Acute esophageal necrosis induced by immune checkpoint inhibitors.

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 2021 Nov 16;; — 2021 Nov 16

Horisberger A, La Rosa S, Zurcher JP, Zimmermann S, Spertini F, Coukos G, Obeid M

A severe case of refractory esophageal stenosis induced by nivolumab and responding to tocilizumab therapy.

Journal for immunotherapy of cancer 2018 12 27;6;156 — 2018 12 27 — 156