The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Ben Mrad I, Ben Mrad M, Oumaya Z, Zairi I, Besbes B, Ouaghlani K, Kamoun S, Mleyhi S, Miri R, Mzoughi K, Kraiem S

Alveolar Hemorrhage Following Thrombolytic Therapy for Acute Myocardial Infarction: Two Case Reports and Literature Review.

Open access emergency medicine : OAEM. 2021;13:399-405

Prasad K, Singh P, Kanabar K, Vijayvergiya R

Pulmonary haemorrhage following thrombolysis with streptokinase in myocardial infarction.

BMJ case reports. 2020;13(1)

González A, Sagardía J, Redondo A, Villaverde M, Monteverde A

[Alveolar hemorrhage as a complication of thrombolytic therapy].

Medicina. 2011;71(6):547-9

Yigla M, Sprecher E, Azzam Z, Guralnik L, Kapeliovich M, Krivoy N

Diffuse alveolar hemorrhage following thrombolytic therapy for acute myocardial infarction.

Respiration; international review of thoracic diseases. 2000;67(4):445-8

Masip J, Vecilla F, Páez J

Diffuse pulmonary hemorrhage after fibrinolytic therapy for acute myocardial infarction.

International journal of cardiology. 1998;63(1):95-7

Swanson GA, Kaeley G, Geraci SA

Diffuse pulmonary hemorrhage after streptokinase administration for acute myocardial infarction.

Pharmacotherapy. 1997;17(2):390-4

Awadh N, Ronco JJ, Bernstein V, Gilks B, Wilcox P

Spontaneous pulmonary hemorrhage after thrombolytic therapy for acute myocardial infarction.

Chest. 1994;106(5):1622-4

Disler LJ, Rosendorff A

Pulmonary hemorrhage following intravenous streptokinase for acute myocardial infarction.

International journal of cardiology. 1990;29(3):387-90