The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Martin TR, Sandblom RL, Johnson RJ

Adult respiratory distress syndrome following thrombolytic therapy for pulmonary embolism.

Chest 1983 Jan;83;151-3 — 1983 Jan — 151-3

Kerstein MD, Adinolfi MF

Pulmonary dysfunction associated with streptokinase therapy.

Archives of surgery (Chicago, Ill. : 1960) 1986 Jul;121;852-3 — 1986 Jul — 852-3

Tio RA, Voorbij RH, Enthoven R

Adult respiratory distress syndrome after streptokinase.

The American journal of cardiology 1992 Dec 15;70;1632-3 — 1992 Dec 15 — 1632-3