The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.p

QTc prolongation

Publications

Ikebe S, Amiya R, Minami S, Ihara S, Higuchi Y, Komuta K

Osimertinib-induced cardiac failure with QT prolongation and torsade de pointes in a patient with advanced pulmonary adenocarcinoma.

International cancer conference journal. 2021;10(1):68-71

Schiefer M, Hendriks LEL, Dinh T, Lalji U, Dingemans AC

Current perspective: Osimertinib-induced QT prolongation: new drugs with new side-effects need careful patient monitoring.

European journal of cancer (Oxford, England : 1990). 2018;91:92-98