The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.t

Heart block (bundle branch- or AV-)

Publications

Bukamur HS, Mezughi H, Karem E, Shahoub I, Shweihat Y

Nivolumab-induced Third Degree Atrioventricular Block in a Patient with Stage IV Squamous Cell Lung Carcinoma.

Cureus 2019 Jun 10;11;e4869 — 2019 Jun 10 — e4869

Tan JL, Mugwagwa AN, Cieslik L, Joshi R

Nivolumab-induced myocarditis complicated by complete atrioventricular block in a patient with metastatic non-small cell lung cancer.

BMJ case reports 2019 Jul 11;12; — 2019 Jul 11

Behling J, Kaes J, Münzel T, Grabbe S, Loquai C

New-onset third-degree atrioventricular block because of autoimmune-induced myositis under treatment with anti-programmed cell death-1 (nivolumab) for metastatic melanoma.

Melanoma research 2017 04;27;155-158 — 2017 04 — 155-158