The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.y

Pulmonary hypertension of the newborn (Persistent PHT)

Publications

Kim SY, Shin SH, Kim HS, Jung YH, Kim EK, Choi JH

Pulmonary Arterial Hypertension after Ibuprofen Treatment for Patent Ductus Arteriosus in Very Low Birth Weight Infants.

The Journal of pediatrics. 2016;179:49-53.e1

Bravo MC, Cordeiro M, Deiros L, Pérez-Rodríguez J

Lethal pulmonary hypertension associated with ibuprofen treatment in a very low birth weight infant.

Journal of paediatrics and child health. 2014;50(1):85-6

Amendolia B, Lynn M, Bhat V, Ritz SB, Aghai ZH

Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates.

Pediatrics. 2012;129(5):e1360-3

Bellini C, Campone F, Serra G

Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2006;174(13):1843-4