The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIX.i

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

Publications

Hadley A, Slaven JE, Krupp NL, Kloepfer KM

Nonsteroidal anti-inflammatory drug hypersensitivity in a pediatric severe asthmatic population.

Pediatric pulmonology 2023 Oct;58 — 2023 Oct — 2983-2986

Guvenir H, Dibek Misirlioglu E, Vezir E, Toyran M, Ginis T, Civelek E, Kocabas CN

Nonsteroidal anti-inflammatory drug hypersensitivity among children.

Allergy and asthma proceedings 2015 Sep-Oct;36;386-93 — 2015 Sep-Oct — 386-93

Blanca-López N, Cornejo-García JA, Plaza-Serón MC, Doña I, Torres-Jaén MJ, Canto G, Padilla-España L, Kidon M, Perkins JR, Blanca M

Hypersensitivity to Nonsteroidal Anti-inflammatory Drugs in Children and Adolescents: Cross-Intolerance Reactions.

Journal of investigational allergology & clinical immunology 2015;25;259-69 — 2015 — 259-69