The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.n

Hemopericardium - Bloody pericardial effusion

Publications

Jain V, Abou Hassan OK, Chetrit M, Bansal A, Gad MM, Kassis N, Klein AL

A Complicated Case of Transient Constrictive Pericarditis Secondary to Rivaroxaban-Associated Hemopericardium.

JACC. Case reports 2020 Oct;2;1947-1950 — 2020 Oct — 1947-1950

Kham NM, Song M

Spontaneous, Life-Threatening Hemorrhagic Cardiac Tamponade Secondary to Rivaroxaban.

American journal of therapeutics 2016 Jul-Aug;23;e1128-31 — 2016 Jul-Aug — e1128-31

Shivamurthy P, Brar N, Therrien ML

Isolated hemopericardium associated with rivaroxaban: first case report.

Pharmacotherapy 2014 Sep;34;e169-72 — 2014 Sep — e169-72

Xu B, MacIsaac A

Life-threatening haemorrhagic pericarditis associated with rivaroxaban.

International journal of cardiology 2014 Jun 15;174;e75-6 — 2014 Jun 15 — e75-6