The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Histoplamosis (reactivation)
Publications
Case records of the Massachusetts General Hospital. Case 32-2014. A 78-year-old woman with chronic sore throat and a tonsillar mass.
The New England journal of medicine. 2014;371(16):1535-43
Hepatitis and pneumonitis during adalimumab therapy in Crohn disease: mind the histoplasmosis!
Arquivos de gastroenterologia. 2014;51(1):73-6
Histoplasmosis infection in patients with rheumatoid arthritis, 1998-2009.
BMC infectious diseases. 2011;11:145
Reactivation histoplasmosis after treatment with anti-tumor necrosis factor alpha in a patient from a nonendemic area.
Respiratory medicine. 2006;100(7):1291-3
Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy.
American journal of respiratory and critical care medicine. 2003;167(9):1279-82
Lee JH, Slifman NR, Gershon SK, Edwards ET, Schwieterman WD, Siegel JN, Wise RP, Brown SL, Udall JN Jr, Braun MM
Life-threatening histoplasmosis complicating immunotherapy with tumor necrosis factor alpha antagonists infliximab and etanercept.
Arthritis and rheumatism. 2002;46(10):2565-70
Reactivation of histoplasmosis after treatment with infliximab.
The American journal of medicine. 2002;112(1):78