The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.b

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Publications

Fernandes V, Alfaro TM, Baptista JP, Regateiro FS, Fradinho F, Cordeiro CR

Severe ketorolac-induced asthma diagnosed by chest computed tomography.

Journal of thoracic disease 2017 Nov;9;S1567-S1569 — 2017 Nov — S1567-S1569

Campobasso CP, Procacci R, Caligara M

Fatal adverse reaction to ketorolac tromethamine in asthmatic patient.

The American journal of forensic medicine and pathology 2008 Dec;29;358-63 — 2008 Dec — 358-63

Kashiwabara K, Nakamura H

Analgesic-induced asthma caused by 2.0% ketoprofen adhesive agents, but not by 0.3% agents.

Internal medicine (Tokyo, Japan) 2001 Feb;40;124-6 — 2001 Feb — 124-6

Hebert WG, Scopelitis E

Ketorolac-precipitated asthma.

Southern medical journal 1994 Feb;87;282-3 — 1994 Feb — 282-3