The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Salberg DJ, Simon MR

Severe asthma induced by naproxen--a case report and review of the literature.

Annals of allergy. 1980;45(6):372-5

Lewis RV

Severe asthma after naproxen.

Lancet (London, England). 1987;1(8544):1270

Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G, Pieton R

Asthmatic attacks induced in aspirin-sensitive patients by diclofenac and naproxen.

British medical journal. 1977;2(6081):231-2