The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Zhong Z, Liu M, Zhong Q, Zhou M, Di X

Drug-induced pulmonary edema: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS).

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2025;58;e14566 — 2025

Joseph M, Amin K, Siddens C, Jaime G, Seeger CM, Mercer K, Chau T

Pulmonary edema after naloxone administration for opioid reversal: a systematic review of case reports and causality assessment using the Naranjo scale.

Clinical toxicology (Philadelphia, Pa.) 2024 May;62;334-342 — 2024 May — 334-342

Conley KD, Murphy-Parker D, Conley VM

Non-Cardiogenic Pulmonary and Peripheral Edema as an Untoward Reaction of Naloxone.

Journal of addictions nursing 2024 Apr-Jun 01;35;114 — 2024 Apr-Jun 01 — 114

Marsalisi C, Guo HJ, Reddy P

The Double-Edged Sword: Naloxone-Induced Noncardiogenic Pulmonary Edema.

Cureus 2023 Jul;15;e41642 — 2023 Jul — e41642

Kummer RL, Kempainen RR, Olives TD, Leatherman JW, Prekker ME

Naloxone-associated pulmonary edema following recreational opioid overdose: A case series.

The American journal of emergency medicine 2021 Dec 17;53;41-43 — 2021 Dec 17 — 41-43

Al-Azzawi M, Alshami A, Douedi S, Al-Taei M, Alsaoudi G, Costanzo E

Naloxone-Induced Acute Pulmonary Edema is Dose-Dependent: A Case Series.

The American journal of case reports 2021 Mar 17;22;e929412 — 2021 Mar 17 — e929412

Elkattawy S, Alyacoub R, Ejikeme C, Noori MAM, Remolina C

Naloxone induced pulmonary edema.

Journal of community hospital internal medicine perspectives 2021 Jan 26;11;139-142 — 2021 Jan 26 — 139-142

Patti R, Ponnusamy V, Somal N, Sinha A, Sharma S, Yoon TS, Kupfer Y

Naloxone-Induced Noncardiogenic Pulmonary Edema.

American journal of therapeutics 2020;27;e672-e673 — 2020

Jiwa N, Sheth H, Silverman R

Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report.

Drug safety - case reports 2018 May 10;5;20 — 2018 May 10 — 20

Lassen CL, Zink W, Wiese CH, Graf BM, Wiesenack C

[Naloxone-induced pulmonary edema. Case report with review of the literature and critical evaluation].

Der Anaesthesist 2012 Feb;61;129-36 — 2012 Feb — 129-36

Nath SS, Tripathi M, Pandey C, Rao B

Naloxone-induced pulmonary edema: a potential cause of postoperative morbidity in laparoscopic donor nephrectomy.

Indian journal of medical sciences 2009 Feb;63;72-5 — 2009 Feb — 72-5

Osterwalder JJ

Naloxone--for intoxications with intravenous heroin and heroin mixtures--harmless or hazardous? A prospective clinical study.

Journal of toxicology. Clinical toxicology 1996;34;409-16 — 1996 — 409-16

Prough DS, Roy R, Bumgarner J, Shannon G

Acute pulmonary edema in healthy teenagers following conservative doses of intravenous naloxone.

Anesthesiology 1984 May;60;485-6 — 1984 May — 485-6

Taff RH

Pulmonary edema following naloxone administration in a patient without heart disease.

Anesthesiology 1983 Dec;59;576-7 — 1983 Dec — 576-7

Partridge BL, Ward CF

Pulmonary edema following low-dose naloxone administration.

Anesthesiology 1986 Dec;65;709-10 — 1986 Dec — 709-10

Schwartz JA, Koenigsberg MD

Naloxone-induced pulmonary edema.

Annals of emergency medicine 1987 Nov;16;1294-6 — 1987 Nov — 1294-6

Brimacombe J, Archdeacon J, Newell S, Martin J

Two cases of naloxone-induced pulmonary oedema--the possible use of phentolamine in management.

Anaesthesia and intensive care 1991 Nov;19;578-80 — 1991 Nov — 578-80

Flacke JW, Flacke WE, Williams GD

Acute pulmonary edema following naloxone reversal of high-dose morphine anesthesia.

Anesthesiology 1977 Oct;47;376-8 — 1977 Oct — 376-8