The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Segura A, Yuste A, Cercos A, López-Tendero P, Gironés R, Pérez-Fidalgo JA, Herranz C

Pulmonary fibrosis induced by cyclophosphamide.

The Annals of pharmacotherapy 2001 Jul-Aug;35;894-7 — 2001 Jul-Aug — 894-7

Malik SW, Myers JL, DeRemee RA, Specks U

Lung toxicity associated with cyclophosphamide use. Two distinct patterns.

American journal of respiratory and critical care medicine 1996 Dec;154;1851-6 — 1996 Dec — 1851-6