The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.t

Heart block (bundle branch- or AV-)

Publications

Mahadevappa M, Pura Krishnamurthy K, Attri LK, Chandrappa Y, Kulkarni P

Rare complication of doxorubicin-induced complete heart block in a patient with Hodgkin's lymphoma: a case report.

European journal of hospital pharmacy : science and practice 2023 Sep;30;e26 — 2023 Sep — e26

Kilickap S, Akgul E, Aksoy S, Aytemir K, Barista I

Doxorubicin-induced second degree and complete atrioventricular block.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2005 May;7;227-30 — 2005 May — 227-30

Pötzi P, Huber J, Kühböck J, Weber H

[ECG changes in adriamycin therapy].

Acta medica Austriaca. Supplement 1979;6;339-41 — 1979 — 339-41