The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.a

Angioedema (may cause UAO, asphyxia and death)

Detrimental interaction with ACEi may be responsible for the angioedema

Publications

Ejikeme C, Nwachukwu C, Viechweg JL, Ejikeme I, Brescia M

DPP-IV Inhibitor-Associated Angioedema in Patient With Known History of ACE Inhibitor Angioedema.

Journal of investigative medicine high impact case reports 2021 Jan-Dec;9;23247096211033049 — 2021 Jan-Dec — 23247096211033049

Bas M, Greve J, Strassen U, Khosravani F, Hoffmann TK, Kojda G

Angioedema induced by cardiovascular drugs: new players join old friends.

Allergy 2015 Oct;70;1196-200 — 2015 Oct — 1196-200

Fain O, Mekinian A, Gobert D, Khau CA, Javaud N

[Drug induced angioedema (ACE-inhibitors and other)].

Presse medicale (Paris, France : 1983) 2015 Jan;44;43-7 — 2015 Jan — 43-7

Millot I, Plancade D, Hosotte M, Landy C, Nadaud J, Ragot C, Graffin B, Drouet C, Kanny G

Treatment of a life-threatening laryngeal bradykinin angio-oedema precipitated by dipeptidylpeptidase-4 inhibitor and angiotensin-I converting enzyme inhibitor with prothrombin complex concentrates.

British journal of anaesthesia 2012 Nov;109;827-9 — 2012 Nov — 827-9