The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

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Path: Pleuroparenchymal fibrosis/fibroelastosis (PPFE)

Publications

Fujikura Y, Kanoh S, Kouzaki Y, Hara Y, Matsubara O, Kawana A

Pleuroparenchymal fibroelastosis as a series of airway complications associated with chronic graft-versus-host disease following allogeneic bone marrow transplantation.

Internal medicine (Tokyo, Japan) 2014;53;43-6 — 2014 — 43-6

Ofek E, Sato M, Saito T, Wagnetz U, Roberts HC, Chaparro C, Waddell TK, Singer LG, Hutcheon MA, Keshavjee S, Hwang DM

Restrictive allograft syndrome post lung transplantation is characterized by pleuroparenchymal fibroelastosis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013 Mar;26;350-6 — 2013 Mar — 350-6