The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII.c

Chest wall muscle rigidity - Stiff/wooden chest

Publications

Wei L, Chen Y

Neuroleptic malignant-like syndrome with a slight elevation of creatine-kinase levels and respiratory failure in a patient with Parkinson's disease.

Patient preference and adherence 2014;8;271-3 — 2014 — 271-3

Chandran GJ, Mikler JR, Keegan DL

Neuroleptic malignant syndrome: case report and discussion.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2003 Sep 02;169;439-42 — 2003 Sep 02 — 439-42