The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVII.g

Tuberculosis (pulmonary, pulmonary, extrapulmonary or disseminated). Reactivation or de novo

Publications

Silva M, Braga J, Fernandes C, Ferreira JM, Marques C, Silva CC, Costa CL

Disseminated Tuberculosis Associated With Adalimumab Therapy.

Journal of medical cases. 2021;12(9):343-346

Benchoukroun S, Gaillard S, Vermersch-Langlin A, Deregnaucourt D

Disseminated tuberculosis complicated by immune reconstitution inflammatory syndrome under anti-TNF treatment.

European journal of dermatology : EJD. 2020;30(3):322-323

Agudo B, Díaz G, González-Lama Y

Adalimumab-Receiving Ulcerative Colitis Patient Suffered Latent Tuberculosis Reactivation Despite Correct Chemoprophylaxis and was Successfully Treated while on Anti-Tumour Necrosis Factor Therapy.

Journal of Crohn's & colitis. 2016;10(12):1453-1454

Assante LR, Barra E, Bocchino M, Zuccarini G, Ferrara G, Sanduzzi A

Tuberculosis of the tongue in a patient with rheumatoid arthritis treated with methotrexate and adalimumab.

Le infezioni in medicina. 2014;22(2):144-8

Caldera F, Grimes I, Soni A

Reactivation of latent tuberculosis in a Crohn's patient after TB prophylaxis treated with adalimumab.

The American journal of gastroenterology. 2013;108(7):1181-2

Martínez-Caselles A, Martínez-Pascual C, Muñoz-Tornero M, Sánchez-Torres A, Carballo-Álvarez F

Tuberculous monoarthritis after treatment with adalimumab in Crohn's disease.

Revista espanola de enfermedades digestivas. 2012;104(3):157-8

Barouta G, Karapetsa M, Kostopoulou E, Alexiou I, Koukoulis G, Sakkas LI

Oral tuberculosis in a patient with rheumatoid arthritis after long treatment with methotrexate and adalimumab.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2010;16(7):330-1

Yoo WH

Multiple organ tuberculosis of lung, pleura, and peritoneum in ankylosing spondylitis during adalimumab therapy.

Rheumatology international. 2012;32(3):787-90

Azevedo VF, Parchen C, Coelho SA, Lacerda DC, Hirth CG

Tuberculous myositis in a patient with ankylosing spondylitis treated with adalimumab.

Rheumatology international. 2009;29(11):1381-4