The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Publications

Campobasso CP, Procacci R, Caligara M

Fatal adverse reaction to ketorolac tromethamine in asthmatic patient.

The American journal of forensic medicine and pathology. 2008;29(4):358-63

Kashiwabara K, Nakamura H

Analgesic-induced asthma caused by 2.0% ketoprofen adhesive agents, but not by 0.3% agents.

Internal medicine (Tokyo, Japan). 2001;40(2):124-6

Chen AH, Bennett CR

Ketorolac-induced bronchospasm in an aspirin-intolerant patient.

Anesthesia progress. 1994;41(4):102-7

Zikowski D, Hord AH, Haddox JD, Glascock J

Ketorolac-induced bronchospasm.

Anesthesia and analgesia. 1993;76(2):417-9

Hebert WG, Scopelitis E

Ketorolac-precipitated asthma.

Southern medical journal. 1994;87(2):282-3