The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary edema, noncardiogenic (NCPE)
Publications
Unmasking a rare contrast reaction: acute non-cardiogenic pulmonary oedema after iohexol injection.
BMJ case reports. 2026;19(7)
Fatal noncardiogenic pulmonary edema related to nonionic, iso-osmolar iodine contrast medium: one case report.
BMC pulmonary medicine. 2022;22(1):118
Acute pulmonary edema induced by non-ionic low-osmolar radiographic contrast media.
Open access emergency medicine : OAEM. 2018;10:75-79
[Pulmonary oedema subsequent to radiographic contrast in a computed tomography of the coronary arteries].
Ugeskrift for laeger. 2012;174(19):1316-7
Case reports of death after nonionic iodine contrast medium injection during spiral computed tomography scan performed for suspected pulmonary embolism.
The American journal of emergency medicine. 2006;24(4):497-9
Review article: Effects of radiographic contrast media on the lung.
The British journal of radiology. 2003;76(905):290-5
Fatal non-cardiogenic pulmonary oedema after intravenous non-ionic radiographic contrast.
Lancet (London, England). 2002;359(9311):1037-8
Pulmonary edema following intravenous injection of nonionic low-osmolar contrast medium--appearance on HRCT. A case report.
Acta radiologica (Stockholm, Sweden : 1987). 1998;39(1):81-3
Non-cardiogenic pulmonary oedema after intravenous administration of non-ionic contrast media.
Acta radiologica (Stockholm, Sweden : 1987). 1996;37(5):823-5
Noncardiogenic pulmonary edema induced by nonionic low-osmolality radiographic contrast media.
The Journal of allergy and clinical immunology. 1995;96(5 Pt 1):698-9
Non-cardiogenic pulmonary edema following intravenous pyelography.
Connecticut medicine. 1982;46(4):180-2
Radiographic contrast media-induced noncardiogenic pulmonary edema: case report and review of the literature.
The Journal of allergy and clinical immunology. 1984;74(1):104-7
Retinal embolism after hysterosalpingography.
The British journal of ophthalmology. 1973;57(3):166-9
Noncardiogenic pulmonary edema resulting from intravascular administration of contrast material.
AJR. American journal of roentgenology. 1991;157(2):255-6
Noncardiogenic pulmonary edema associated with intravenous radiocontrast administration.
Chest. 1992;102(2):620-1
Shock lung with massive tracheal loss of plasma.
JAMA. 1977;237(23):2511-3