The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary edema, noncardiogenic (NCPE)
Publications
Unmasking a rare contrast reaction: acute non-cardiogenic pulmonary oedema after iohexol injection.
BMJ case reports 2026 Jul 03;19; — 2026 Jul 03
Fatal noncardiogenic pulmonary edema related to nonionic, iso-osmolar iodine contrast medium: one case report.
BMC pulmonary medicine 2022 Mar 31;22;118 — 2022 Mar 31 — 118
Acute pulmonary edema induced by non-ionic low-osmolar radiographic contrast media.
Open access emergency medicine : OAEM 2018;10;75-79 — 2018 — 75-79
[Pulmonary oedema subsequent to radiographic contrast in a computed tomography of the coronary arteries].
Ugeskrift for laeger 2012 May 07;174;1316-7 — 2012 May 07 — 1316-7
Case reports of death after nonionic iodine contrast medium injection during spiral computed tomography scan performed for suspected pulmonary embolism.
The American journal of emergency medicine 2006 Jul;24;497-9 — 2006 Jul — 497-9
Review article: Effects of radiographic contrast media on the lung.
The British journal of radiology 2003 May;76;290-5 — 2003 May — 290-5
Fatal non-cardiogenic pulmonary oedema after intravenous non-ionic radiographic contrast.
Lancet (London, England) 2002 Mar 23;359;1037-8 — 2002 Mar 23 — 1037-8
Pulmonary edema following intravenous injection of nonionic low-osmolar contrast medium--appearance on HRCT. A case report.
Acta radiologica (Stockholm, Sweden : 1987) 1998 Jan;39;81-3 — 1998 Jan — 81-3
Non-cardiogenic pulmonary oedema after intravenous administration of non-ionic contrast media.
Acta radiologica (Stockholm, Sweden : 1987) 1996 Sep;37;823-5 — 1996 Sep — 823-5
Noncardiogenic pulmonary edema induced by nonionic low-osmolality radiographic contrast media.
The Journal of allergy and clinical immunology 1995 Nov;96;698-9 — 1995 Nov — 698-9
Non-cardiogenic pulmonary edema following intravenous pyelography.
Connecticut medicine 1982 Apr;46;180-2 — 1982 Apr — 180-2
Radiographic contrast media-induced noncardiogenic pulmonary edema: case report and review of the literature.
The Journal of allergy and clinical immunology 1984 Jul;74;104-7 — 1984 Jul — 104-7
Retinal embolism after hysterosalpingography.
The British journal of ophthalmology 1973 Mar;57;166-9 — 1973 Mar — 166-9
Noncardiogenic pulmonary edema resulting from intravascular administration of contrast material.
AJR. American journal of roentgenology 1991 Aug;157;255-6 — 1991 Aug — 255-6
Noncardiogenic pulmonary edema associated with intravenous radiocontrast administration.
Chest 1992 Aug;102;620-1 — 1992 Aug — 620-1
Shock lung with massive tracheal loss of plasma.
JAMA 1977 Jun 06;237;2511-3 — 1977 Jun 06 — 2511-3