The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.q

Tongue involvement (edema, glossitis, hematoma)

Publications

Diestro JDB, Sedano LSP, Reyes NGD, San Jose MCZ

Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2019;28(5):e44-e45

Correia AS, Matias G, Calado S, Lourenço A, Viana-Baptista M

Orolingual angiodema associated with alteplase treatment of acute stroke: a reappraisal.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2015;24(1):31-40

Ottomeyer C, Sick C, Hennerici MG, Szabo K

[Orolingual angioedema under systemic thrombolysis with rt-PA: an underestimated side effect].

Der Nervenarzt. 2009;80(4):459-63

Hill MD, Barber PA, Takahashi J, Demchuk AM, Feasby TE, Buchan AM

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2000;162(9):1281-4