The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIX.u

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

There is a possible asscoation of thyroid disease and ANCA-related vasculitis, irrespective of exposure to antithyroid drugs (PMID 17686815)

Publications

Arnold S, Kitching AR, Witko-Sarsat V, Wiech T, Specks U, Klapa S, Comdühr S, Stähle A, Müller A, Lamprecht P

Myeloperoxidase-specific antineutrophil cytoplasmic antibody-associated vasculitis.

The Lancet. Rheumatology 2024 May;6;e300-e313 — 2024 May

Culerrier J, Nguyen Y, Karadag O, Yasar Bilge S, Yildrim TD, Ögüt TS, Yazisiz V, Bes C, Celfe A, Yazici A, Sadioglu Cagdas O, Kronbichler A, Jayne D, Gauckler P, Regent A, Teixeira V, Marchand-Adam S, Duffau P, Ingen-Housz-Oro S, Droumaguet C, Andre B, Lu

Characteristics and outcome of ANCA-associated vasculitides induced by anti-thyroid drugs: a multicenter retrospective case-control study.

Rheumatology (Oxford, England) 2023 Jun 24;; — 2023 Jun 24

Balavoine AS, Glinoer D, Dubucquoi S, Wémeau JL

Antineutrophil Cytoplasmic Antibody-Positive Small-Vessel Vasculitis Associated with Antithyroid Drug Therapy: How Significant Is the Clinical Problem?

Thyroid : official journal of the American Thyroid Association 2015 Dec;25;1273-81 — 2015 Dec — 1273-81

Dolman KM, Gans RO, Vervaat TJ, Zevenbergen G, Maingay D, Nikkels RE, Donker AJ, von dem Borne AE, Goldschmeding R

Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.

Lancet (London, England) 1993 Sep 11;342;651-2 — 1993 Sep 11 — 651-2