The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Methemoglobinemia
Publications
Symptomatic methemoglobinemia with a commonly used topical anesthetic, cetacaine.
The Annals of thoracic surgery 1980 Aug;30;187-90 — 1980 Aug — 187-90
Methemoglobinemia induced by a topical anesthetic spray (cetacaine).
Chest 1977 May;71;587-91 — 1977 May — 587-91