The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.z

Progression, acceleration or exacerbation of preexisting ILD/fibrosis

Publications

Foster B, Wagman LD

Surgical stress-induced oxaliplatin-associated interstitial pneumonitis.

The American surgeon 2011 Dec;77;E272-3 — 2011 Dec — E272-3

Wilcox BE, Ryu JH, Kalra S

Exacerbation of pre-existing interstitial lung disease after oxaliplatin therapy: a report of three cases.

Respiratory medicine 2008 Feb;102;273-9 — 2008 Feb — 273-9