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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Karaman A, Omeroglu M, Emet M, Kerget B, Subasi ID, Alper F

Lenalidomide Induced Late-Onset Acute Respiratory Distress Syndrome.

The Eurasian journal of medicine. 2016;48(3):228-229

Gibelin A, Parrot A, Maitre B, Brun-Buisson C, Mekontso Dessap A, Fartoukh M, de Prost N

Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition.

Intensive care medicine. 2016;42(2):164-72

Mankikian J, Lioger B, Diot E, D'Halluin P, Lissandre S, Marchand Adam S, Mercier E, Beau Salinas F

Pulmonary toxicity associated with the use of lenalidomide: case report of late-onset acute respiratory distress syndrome and literature review.

Heart & lung : the journal of critical care. 2014;43(2):120-3

Danbara M, Tadera N, Togano T, Katayama T, Aoki T, Miyazaki K, Higashihara M

Lenalidomide-induced acute lung injury in case of multiple myeloma.

International journal of clinical pharmacology and therapeutics. 2013;51(6):513-6