The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.c

Chest wall muscle rigidity - Stiff/wooden chest

Publications

Zoorob R, Uptegrove L, Park BL

Case Report of Very-Low-Dose Fentanyl Causing Fentanyl-Induced Chest Wall Rigidity.

Cureus. 2023;15(8):e43788

Tammen AJ, Brescia D, Jonas D, Hodges JL, Keith P

Fentanyl-Induced Rigid Chest Syndrome in Critically Ill Patients.

Journal of intensive care medicine. 2023;38(2):196-201

Rosal NR, Thelmo FL Jr, Tzarnas S, DiCalvo L, Tariq S, Grossman C

Wooden Chest Syndrome: A Case Report of Fentanyl-Induced Chest Wall Rigidity.

Journal of investigative medicine high impact case reports. 2021;9:23247096211034036

Frisoni P, Bacchio E, Bilel S, Talarico A, Gaudio RM, Barbieri M, Neri M, Marti M

Novel Synthetic Opioids: The Pathologist's Point of View.

Brain sciences. 2018;8(9)

Phua CK, Wee A, Lim A, Abisheganaden J, Verma A

Fentanyl-induced chest wall rigidity syndrome in a routine bronchoscopy.

Respiratory medicine case reports. 2017;20:205-207

Çoruh B, Tonelli MR, Park DR

Fentanyl-induced chest wall rigidity.

Chest. 2013;143(4):1145-1146

Eventov-Friedman S, Rozin I, Shinwell ES

Case of chest-wall rigidity in a preterm infant caused by prenatal fentanyl administration.

Journal of perinatology : official journal of the California Perinatal Association. 2010;30(2):149-50

Müller P, Vogtmann C

Three cases with different presentation of fentanyl-induced muscle rigidity--a rare problem in intensive care of neonates.

American journal of perinatology. 2000;17(1):23-6

Fahnenstich H, Steffan J, Kau N, Bartmann P

Fentanyl-induced chest wall rigidity and laryngospasm in preterm and term infants.

Critical care medicine. 2000;28(3):836-9

Ackerman WE, Phero JC, Theodore GT

Ineffective ventilation during conscious sedation due to chest wall rigidity after intravenous midazolam and fentanyl.

Anesthesia progress. 1990;37(1):46-8