The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.k

Sarcoid-like granulomatosis (endo-/extrathoracic)

Publications

Plant R, Rafi Ahmed A, Mchale T, Giblin L

A Case of Adalimumab-Induced Granulomatous Interstitial Nephritis.

Cureus. 2021;13(6):e15986

Louro M, Vaio T, Crespo J, Santos R, Carvalho A

Pulmonary Sarcoidosis in Behçet's Disease Treated with Adalimumab.

European journal of case reports in internal medicine. 2017;4(4):000576

Sandys V, Moloney B, Lane L, Qazi J, Doyle B, Barry M, Leavey S, Conlon P

Granulomatous interstitial nephritis secondary to adalimumab therapy.

Clinical kidney journal. 2018;11(2):219-221

Jung JH, Kim JH, Song GG

Adalimumab-induced pulmonary sarcoidosis not progressing upon treatment with etanercept.

Zeitschrift fur Rheumatologie. 2017;76(4):372-374

Au S, Mirsaeidi M, Aronson IK, Sweiss NJ

Adalimumab Induced Subcutaneous Nodular Sarcoidosis; A Rare Side Effect of Tumor Necrosis Factor-α Inhibitor.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 2014;31(3):249-51

Abdallah T, Abdallah M, Saifan C, El Sayegh D, Chalhoub M, Sasso L

Hemidiaphragm paresis and granulomatous pneumonitis associated with adalimumab: a case report.

Heart & lung : the journal of critical care. 2014;43(1):84-6

Kanellopoulou T, Filiotou A, Kranidioti H, Dourakis SP

Sarcoid-like granulomatosis in patients treated with anti-TNFα factors. A case report and review of the literature.

Clinical rheumatology. 2011;30(4):581-3