The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XVII.e

Pneumocystis jiroveci pneumonia

Publications

Perrier Q, Portais A, Terrec F, Cerba Y, Romanet T, Malvezzi P, Bedouch P, Tetaz R, Rostaing L

A Case of Pneumocystis jirovecii Pneumonia under Belatacept and Everolimus: Benefit-Risk Balance between Renal Allograft Function and Infection.

Case reports in nephrology and dialysis. 2021;11(1):10-15

Nakamura M, Matsunuma R, Yamaguchi K, Hayami R, Tsuneizumi M

Pneumocystis Pneumonia and Acute Kidney Injury Induced by Everolimus Treatment in a Patient with Metastatic Breast Cancer.

Case reports in oncology. 2020;13(1):170-175

Goldberg HJ, Harari S, Cottin V, Rosas IO, Peters E, Biswal S, Cheng Y, Khindri S, Kovarik JM, Ma S, McCormack FX, Henske EP

Everolimus for the treatment of lymphangioleiomyomatosis: a phase II study.

The European respiratory journal. 2015;46(3):783-94

Kuik KT, Trubiano J, Worth LJ, Harun NS, Steinfort D, Johnson D

Pneumocystis jirovecii pneumonia following everolimus treatment of metastatic breast cancer.

Medical mycology case reports. 2014;6:34-6

Carbonnaux M, Molin Y, Souquet PJ, Tantin A, Lombard-Bohas C, Walter T

Pneumocystis jirovecii pneumonia under everolimus in two patients with metastatic pancreatic neuroendocrine tumors.

Investigational new drugs. 2014;32(6):1308-10

Saito Y, Nagayama M, Miura Y, Ogushi S, Suzuki Y, Noro R, Minegishi Y, Kimura G, Kondo Y, Gemma A

A case of pneumocystis pneumonia associated with everolimus therapy for renal cell carcinoma.

Japanese journal of clinical oncology. 2013;43(5):559-62