The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Methemoglobinemia
Publications
Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis.
Pediatric dermatology 2016 Sep;33;e284-5 — 2016 Sep — e284-5
Lidocaine-induced methemoglobinemia: a clinical reminder.
The Journal of the American Osteopathic Association 2015 Feb;115;94-8 — 2015 Feb — 94-8
[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].
Annales de dermatologie et de venereologie 2012 Dec;139;824-7 — 2012 Dec — 824-7
Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures.
Local and regional anesthesia 2011;4;25-8 — 2011 — 25-8
Application of topical analgesia in triage: a potential for harm.
The Journal of emergency medicine 2008 Jul;35;39-41 — 2008 Jul — 39-41
Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report.
Journal of medical case reports 2008 Jan 23;2;16 — 2008 Jan 23 — 16
Severe methemoglobinemia from topical anesthetic spray: case report, discussion and qualitative systematic review.
CJEM 2001 Jan;3;51-6 — 2001 Jan — 51-6
Severe methemoglobinemia following dental extractions under lidocaine anesthesia.
Anesthesiology 1956 Jan;17;204 — 1956 Jan — 204