The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIV.a

Methemoglobinemia

Publications

Cicek Y, Durakoglugil ME, Usta EH

Methemoglobinemia due to local anesthesia: a rare cause of cyanosis and chest pain after placement of implantable cardioverter defibrillator.

Journal of rural medicine : JRM. 2020;15(2):63-64

Wakita R, Fukayama H

Methemoglobinemia should be suspected when oxygen saturation apparently decreases after prilocaine infiltration during intravenous sedation.

Clinical case reports. 2018;6(6):1077-1081

Cho YS, Chung BY, Park CW, Kim HO

Seizures and Methemoglobinemia After Topical Application of Eutectic Mixture of Lidocaine and Prilocaine on a 3.5-Year-Old Child with Molluscum Contagiosum and Atopic Dermatitis.

Pediatric dermatology. 2016;33(5):e284-5

Yildirim B, Karagoz U, Acar E, Beydilli H, Nese Yeniceri E, Tanriverdi O, Alatas OD, Kasap Ş

A Case Report of Prilocaine-Induced Methemoglobinemia after Liposuction Procedure.

Case reports in emergency medicine. 2015;2015:282347

Schmitt C, Matulic M, Kervégant M, Tichadou L, Boutin A, Glaizal M, de Haro L

[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].

Annales de dermatologie et de venereologie. 2012;139(12):824-7

Adams V, Marley J, McCarroll C

Prilocaine induced methaemoglobinaemia in a medically compromised patient. Was this an inevitable consequence of the dose administered?

British dental journal. 2007;203(10):585-7

Aygencel SG, Akinci E, Pamukcu G

Prilocaine induced methemoglobinemia.

Saudi medical journal. 2006;27(1):111-3

Sinisterra S, Miravet E, Alfonso I, Soliz A, Papazian O

Methemoglobinemia in an infant receiving nitric oxide after the use of eutectic mixture of local anesthetic.

The Journal of pediatrics. 2002;141(2):285-6

Coleman MD, Coleman NA

Drug-induced methaemoglobinaemia. Treatment issues.

Drug safety. 1996;14(6):394-405