The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIV.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Igneri LA, Czosnowski QA, Whitman CB

Methylprednisolone sodium succinate-associated macroglossia in a critically ill patient.

Pharmacotherapy 2013 Feb;33;e14-8 — 2013 Feb — e14-8

Compalati E, Guerra L, Rogkakou A, Zanella C, Scordamaglia A, Passalacqua G

Angioedema after administration of methylprednisolone to treat drug allergy.

Allergy 2007 Nov;62;1346-8 — 2007 Nov — 1346-8