The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
A cause-and-effect relationship is uncertain (PMID 20374322)
Publications
A Rare Side Effect due to TNF-Alpha Blocking Agent: Acute Pleuropericarditis with Adalimumab.
Case reports in rheumatology 2013;2013;985914 — 2013 — 985914
Annapureddy N, Agarwal SK, Ammakkanavar N, Kanakadandi V, Sabharwal MS, Sanjani HP, Simoes P, Nadkarni GN
Tumor necrosis factor inhibitor-induced serositis.
American journal of therapeutics 2014 Sep-Oct;21;e166-8 — 2014 Sep-Oct — e166-8