The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.d

Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

Publications

Saito Y, Terasaki Y, Kashiwada T, Tanaka T, Takei H, Kimura G, Kondo Y, Kawagoe T, Matsushita A, Noro R, Minegishi Y, Kamio K, Seike M, Gemma A

Clinicopathological Characteristics of Everolimus-Associated Interstitial Lung Disease: A Single-Center Consecutive Analysis.

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2024 May 21;91 — 2024 May 21 — 207-217

Kim CJ, McKenzie D, Joseph JK, Aytaman Y, Lam ML, Soni L, McFarlane SI

Refractory Metastatic Insulinoma Treated with Everolimus, Complicated by Cryptogenic Organizing Pneumonia.

American journal of medical case reports 2019;7;125-132 — 2019 — 125-132

Nazer L, Alnajjar T, Salah S, Khzouz J, Alfaqeer N, Qandeel M

Fatal case of cryptogenic organizing pneumonia associated with everolimus.

Annals of Saudi medicine 2014 Sep-Oct;34;437-9 — 2014 Sep-Oct — 437-9

Saito Y, Kunugi S, Suzuki Y, Narita K, Miura Y, Minegishi Y, Kimura G, Kondo Y, Azuma A, Fukuda Y, Gemma A

Granuloma-forming interstitial pneumonia occurring one year after the start of everolimus therapy.

Internal medicine (Tokyo, Japan) 2013;52;263-7 — 2013 — 263-7

Expósito V, de Prada JA, Gómez-Román JJ, González-Vilchez F, Llano-Cardenal M, García-Camarero T, Fernández-Valls M, Ruano J, Martín-Durán R

Everolimus-related pulmonary toxicity in heart transplant recipients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008 Jul;27;797-800 — 2008 Jul — 797-800