The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Kerget B, Aksakal A, Af?in DE, Araz O, Ucar EY, Akgün M, Sa?lam L

Acute respiratory distress syndrome after the use of gadolinium contrast agent.

Respiratory medicine case reports 2018;25;336-338 — 2018 — 336-338

Guru PK, Bohman JK, Fleming CJ, Tan HL, Sanghavi DK, De Moraes AG, Barsness GW, Wittwer ED, King BF, Arteaga GM, Flick R, Schears GJ

Severe Acute Cardiopulmonary Failure Related to Gadobutrol Magnetic Resonance Imaging Contrast Reaction: Successful Resuscitation With Extracorporeal Membrane Oxygenation.

Mayo Clinic proceedings 2016 Mar;91;362-6 — 2016 Mar — 362-6

Park J, Byun IH, Park KH, Lee JH, Nam EJ, Park JW

Acute Respiratory Distress Syndrome after the Use of Gadolinium Contrast Media.

Yonsei medical journal 2015 Jul;56;1155-7 — 2015 Jul — 1155-7

Demirhan A, Yasar Tekelioglu U, Akkaya A, Dagistan E, Suzi Ayhan S, Ozturk S, Yildiz I, Kocoglu H

Magnetic resonance imaging contrast agent related pulmonary edema: a case report.

European review for medical and pharmacological sciences 2012 Oct;16 Suppl 4;110-2 — 2012 Oct — 110-2