The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.e

Cough (acute, violent, explosive)

Propofol may be able to prevent this fentanyl-induced adverse effect (PMID 24223355)

Publications

Firouzian A, Emadi SA, Baradari AG, Mousavi R, Kiasari AZ

Can low dose of propofol effectively suppress fentanyl-induced cough during induction of anaesthesia? A double blind randomized controlled trial.

Journal of anaesthesiology, clinical pharmacology. 2015;31(4):522-5

El Baissari MC, Taha SK, Siddik-Sayyid SM

Fentanyl-induced cough--pathophysiology and prevention.

Middle East journal of anaesthesiology. 2014;22(5):449-56

Generali JA, Cada DJ

Lidocaine: cough (fentanyl induced).

Hospital pharmacy. 2014;49(1):23-5

Sedighinejad A, Naderi Nabi B, Haghighi M, Imantalab V, Hadadi S, Erfani Sayar R, Mirblook A

Propofol is Effective to Depress Fentanyl-Induced Cough during Induction of Anesthesia.

Anesthesiology and pain medicine. 2013;2(4):170-3

Sun L, Guo R, Sun L

The impact of prophylactic intravenous lidocaine on opioid-induced cough: a meta-analysis of randomized controlled trials.

Journal of anesthesia. 2014;28(3):325-33

Kim JE, Min SK, Chae YJ, Lee YJ, Moon BK, Kim JY

Pharmacological and nonpharmacological prevention of fentanyl-induced cough: a meta-analysis.

Journal of anesthesia. 2014;28(2):257-66

Gecaj-Gashi A, Nikolova-Todorova Z, Ismaili-Jaha V, Gashi M

Intravenous lidocaine suppresses fentanyl-induced cough in Children.

Cough (London, England). 2013;9:20

Mukherjee A, Kundu AK, Ghosh S, Choudhuri R, Bandopadhyay BK, Dasgupta S

Pre-emptive oral dexmethorphan reduces fentanyl-induced cough as well as immediate postoperative adrenocortico-tropic hormone and growth hormone level.

Journal of anaesthesiology, clinical pharmacology. 2011;27(4):489-94

Sun ZT, Yang CY, Cui Z, Zhang J, Han XP

Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial.

Journal of anesthesia. 2011;25(6):860-3

Agarwal A, Azim A, Ambesh S, Bose N, Dhiraj S, Sahu D, Singh U

Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced by iv fentanyl.

Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2003;50(3):297-300

Tweed WA, Dakin D

Explosive coughing after bolus fentanyl injection.

Anesthesia and analgesia. 2001;92(6):1442-3