The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Kok LC, Sugihara J, Druger G

First case report of spontaneous pulmonary hemorrhage following heparin therapy in acute myocardial infarction.

Hawaii medical journal 1996 May;55;83-4 — 1996 May — 83-4

Shapiro S, Slone D, Lewis GP, Jick H

Fatal drug reactions among medical inpatients.

JAMA 1971 Apr 19;216;467-72 — 1971 Apr 19 — 467-72