The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LVIII.v

Path: NSIP-fibrotic pattern

Publications

Gupta S, Mahipal A

Fatal pulmonary toxicity after a single dose of cyclophosphamide.

Pharmacotherapy 2007 Apr;27;616-8 — 2007 Apr — 616-8

Malik SW, Myers JL, DeRemee RA, Specks U

Lung toxicity associated with cyclophosphamide use. Two distinct patterns.

American journal of respiratory and critical care medicine 1996 Dec;154;1851-6 — 1996 Dec — 1851-6

Richter JE, Hastedt R, Dalton JF, Marshall D, Raymond LW

Pulmonary toxicity of bischloronitrosourea: report of a case with transient response to corticosteroid therapy.

Cancer 1979 May;43;1607-12 — 1979 May — 1607-12